With the second leg of the Champions League coming up this week, I'm concerned that Fergie may feel safe in his 2-1 lead at home and attempt to try a similar formation. SAF, if you can hear my mental projections, DON'T DO IT. You may not be able to play 4-4-2 while Rooney is out but whatever formation you pick, Berbatov needs a partner. Think about it, he can pass, lob, cross, dribble, and at times do wonderful magic with the ball. But, when you strand him out front, he has no one to pass, lob, and cross to! Macheda is back, Diouf is showing some promise, Welbeck is green but available (I think) so put someone out there with him. Even a 4-4-1-1 with Berbatov as a center forward would work better.
Lastly, Fergie would do well to remember that despite having two away goals, despite playing at home, and despite leading Milan 2-1, it only takes one bit of luck for that score to be tied and then you have to find a way to put the ball in the back of the net again, and this time without your star striker. Given the fact that Milan scored against us in the first five minutes of the San Siro leg, I wouldn't put that event too far into the realms of impossibility.